Immunophenotypic markers to differentiate between benign and malignant melanocytic lesions
نویسندگان
چکیده
منابع مشابه
Immunophenotypic markers to differentiate between benign and malignant melanocytic lesions.
BACKGROUND/AIMS The authors investigated the expression of S100A1, S100A6, S100B, MelanA, and CEA in conjunctival naevi, primary acquired melanosis (PAM), conjunctival melanoma, and uveal melanoma in order to assess their potential usefulness in the pathological differential diagnosis of these entities. METHODS Paraffin embedded sections of 18 conjunctival naevi, 14 PAM, 16 conjunctival melan...
متن کاملMyeloid leukemia-1 expression in benign and malignant melanocytic lesions.
Myeloid leukemia-1 (Mcl-1) is an anti-apoptotic protein implicated in tumor progression. Its expression was found to be elevated in many types of human cancers and is correlated with tumor progression. The expression of Mcl-1 in melanoma is not fully understood. We investigated the expression of Mcl-1 in normal nevi, dysplastic nevi, primary melanoma and melanoma metastases by tissue microarray...
متن کاملAssessment of Prognostic Markers in Benign and Malignant Melanocytic Tumours
Cutaneous melanoma is a malignant tumour that arises from pigmented skin cells – melanocytes, represents the most rapidly increasing cancer worldwide which is causing significant public health problem. During the past decade a significant progress has been made in the understanding of genesis and progression of melanocytic lesions. However treatment of malignant melanomas is in a majority of ca...
متن کاملASSESSMENT OF TUMOR MARKERS IN BENIGN, DYSPLASTIC AND MALIGNANT ORAL MUCOSAL LESIONS
Immunohistochemical demonstration of tumor-associated markers may be valuable as an adjunct to conventional histology for determination of malignancy development in oral mucosal diseases. Accordingly, the present study determined the distribution of some important tumor markers such as heat shock proteins (HSP), fibroblast growth factors (FGF) and transferrin receptors (TF-R) in 22 samples ...
متن کاملAn independent validation of a gene expression signature to differentiate malignant melanoma from benign melanocytic nevi
BACKGROUND Recently, a 23-gene signature was developed to produce a melanoma diagnostic score capable of differentiating malignant and benign melanocytic lesions. The primary objective of this study was to independently assess the ability of the gene signature to differentiate melanoma from benign nevi in clinically relevant lesions. METHODS A set of 1400 melanocytic lesions was selected from...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: British Journal of Ophthalmology
سال: 2006
ISSN: 0007-1161
DOI: 10.1136/bjo.2005.080390